Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 17;12:372. doi: 10.3389/fncel.2018.00372

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Chen, Wang, Zhang, Chen, Yang, Li, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Gap19 prevented the activation of TLR4 pathway and reduced inflammatory cytokines in vitro. (A–D) Western blot and quantitative analysis showed the expression of TLR4, MyD88 and NF-κB p-p65 were decreased by Gap19 after OGD. (E,F) Enzyme-linked immunosorbent assay (ELISA) revealed that Gap19-treated cells exhibited altered release of IL-1β and TNF-α 24 h after reoxygenation. (G,H) The neutralizing antibodies of TNF-α decrease the p-P65 expression and increased the astrocytes viability after OGD. Values (mean ± SEM) are representative of at least three independent experiments. *P < 0.05 vs. the OGD group. ^#P < 0.05 vs. the control group.