FIGURE 5.

Hypothetical model to sensitize GC. DNA damage caused by CDDP leads to activation of NER, XPC is already in the nucleus and proteins XPA and XPD translocate to the nucleus to repair the lesion. Resistant cells repair properly the DNA and survive, however, if repair is not efficient, the mitochondrial apoptosis pathway is induced by Mcl-1 degradation and Bid and Bad induction. Option 1 (red circle) proposes the inhibition of XP proteins, and option 2 (green circle) proposes the use of BH₃ only mimetics.