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. 2018 Oct 17;9:1194. doi: 10.3389/fphar.2018.01194

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Copyright © 2018 Saw, Zhang, Nie, Zhang, Xu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Formulation of the aptide-decorated liposomal nanoplatform (APT-_EDB NPs); (B) schematic illustration of the APT-_EDB NPs for systemic siRNA delivery and targeted GBM treatment. After intravenous injection (a), the long-circulating NPs can accumulate in the GBM tumor tissues (b) and subsequently target the glioma cells via the specific recognition between aptide and EDB (c). After targeted cellular uptake (d,e), the APT-_EDB NPs can release the siRNA in the cytoplasm (f), leading to effective silencing of GBM-associated CypA expression and ultimate inhibition of GBM tumor growth (g).