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. 2018 Oct 17;9:2398. doi: 10.3389/fimmu.2018.02398

Figure 2.

Figure 2

Dopamine inhibits production of IL4 and IFNγ in iNKT cells. (A–C) IL4 and IFNγ production in iNKT cells activated by α-GalCer-pulsed RBL.CD1d cells (A), anti-CD3 plus anti-CD28 (B), and PMA plus ionomycin (C) in the absence or presence of different doses of dopamine. Data are representative of three independent experiments. (D) mRNA levels of Il4 and Ifng in iNKT cells activated by anti-CD3 plus anti-CD28, in the absence or presence of different doses of dopamine. Data are representative of three independent experiments. Error bars represent SEM. *P < 0.05, **P < 0.01, ***P < 0.001. DA, dopamine; PMA, phorbol myristate acetate; Iono, ionomycin.