Table 1.
Summary of the Drosophila based candidate modifier screen
| Human gene | Drosophila homolog | Blast e-value (human to fly) | Effect on motor performance in α-Syn transgenic flies | Modifier allele |
|---|---|---|---|---|
| ACSBG1 | bgm | 2E-172 | Improves | bgm[MI14249] |
| CACNA1S | Ca-alpha1D | 0 | Improves | Ca-alpha1D[MI08906] |
| CACNA1S | cac | 0 | Improves | GD15341(hp RNAi) |
| CDK14 | Eip63E-LOF1 | 2E-159 | Improves | Eip63E[MI00413-GFSTF.1] |
| CDK14 | Eip63E-LOF2 | 2E-159 | Improves | Eip63E[81] |
| CDK14 | Eip63E | 2E-159 | Improves | Eip63E[MI04853]a |
| DDC | Ddc | 0 | Improves | Ddc[ts2] |
| DNER | Notch | 2E-65 | Improves | N[fa-swb] |
| ERBB2 | Egfr | 7E-126 | Improves | slbo(FRT.lacZ)Egfr.RNAi |
| HDAC3 | HDAC1 | 0 | Improves | HDAC1[12–37]a |
| HDAC3 | HDAC3 | 0 | Improves | GD9732(hp RNAi) |
| LGALS3BP | lox2 | 4E-17 | Improves | lox2[MI06311] |
| LOXL1 | lox2 | 8E-55 | Improves | lox2[MI06311] |
aData not shown.