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. 2018 Oct 10;41(10):881–888. doi: 10.14348/molcells.2018.0247

Fig. 1. Process to discover brain somatic mutations in intractable epilepsy.

Fig. 1

(A) Post operation MRI image of epilepsy surgery and specimen collection process. (B) Enrichment of mutation carrying cells for sequencing ready samples. Note that percentage of cells with mutations is much higher than before enrichment. (C) Example of read stacks implying necessity of high coverage depth genome wide sequencing to emphasize epilepsy causing mutation without false negative.