Figure 5. Effects of fermented lingonberry juice (FLJ) and curcumin on the invasiveness of SCC-25 cells after 96 h of exposure. The threedimensionaltumour spheroid invasion assay was used to study the effects of FLJ (A), curcumin (B) and curcumin-loaded extracellular vesicles (C)on OTSCC invasion. Invasion was measured using the ImageJ software. All experiments were repeated independently three times and each intriplicate. Results are the means±standard error. Statistical significance was determined by calculating the area under the curve and using onewayANOVA followed by a Bonferroni post-hoc test. Significantly different at *p≤0.05.