Figure 4. Efficacy of treatment in each group on expression of angiogenesis markers in atherosclerotic plaques. A: Representative immunohistochemicalimages for CD31 expression in normal control, model control, and groups treated with intercellular cell adhesion molecule 1 (ICAM-1)-targetedmicrobubbles (MBi) with ultrasound targeted microbubble delivery (UTMD), and ICAM-1-targeted and Endostar-loaded therapeutic microbubbles(MBie) with UTMD (magnification: upper panel 100×; lower panel 400×). B: Quantitation of the expression of CD31 by average optical density.Significantly different at p<0.01 compared with the *model control group, and #Endostar and MBi+UTMD groups.