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. 2018 Oct 18;2(20):2691–2703. doi: 10.1182/bloodadvances.2018019448

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Figure 4. — MRTFA^OEenhances associations between SRF binding and genes with altered expression. (A) Pie charts illustrating the relationship between dynamic gene expression and SRF binding of those genes. The percentage of genes that have at least 1 associated SRF binding site is shown in the middle of each pie chart and is indicated by the light green wedge. MRTFA^OE during megakaryopoiesis increases the probability of SRF binding close to genes that are upregulated by TPA and MRTFA^OE. (B) Changes in SRF binding among genes that are upregulated, downregulated, or unchanged for each comparison. MRTFA^OE increases not only the number of upregulated genes, but also the SRF binding to these genes during maturation. (C) Integrative Genome Viewer screenshot of SRF binding proximal to the CORO1A locus. MRTFA^OE in HEL cells increases the recruitment of SRF. Replicates of each group are shown. All tracks are normalized in bigwig format.