Table 2.
The patients with STAT3 mutations
| Cohort | UPN | Cause of PRCA | STAT3 mutation | ||
|---|---|---|---|---|---|
| Allele-specific PCR | Amplicon (% PB or BM MNCs) | Amplicon (% CD8+ T) | |||
| Nagano/Kanazawa | 47 | Idiopathic | Y640F, D661Y | Y640F (2.9), D661Y (7.3) | Y640F (6), D661Y (13.7) |
| 166 | Idiopathic | — | G618R (7.8), D698H (2) | NT | |
| 182 | CD, SjS | — | R152W (48.9) | NT | |
| 243 | Idiopathic | — | — | D661V (1.9) | |
| 245 | Thymoma | Y640F | Y640F (2.2) | Y640F (15.8) | |
| 399 | Idiopathic | — | S614R (9.1), Y640F (2.3) | NT | |
| 3 | T-LGLL | Y640F, D661Y | Y640F (5.6), D661Y (1.1) | NT | |
| 8 | T-LGLL | D661Y | D661Y (0.96)* | NT | |
| 13 | T-LGLL | D661Y | D661Y (0.57)* | NT | |
| 37 | T-LGLL | Y640F | Y640F (3.1) | NT | |
| 170 | T-LGLL | D661Y | D661Y (1.2) | S614R (1.5),† D661Y (1.2)† | |
| 192 | T-LGLL | — | D661H (4.8) | NT | |
| 194 | T-LGLL | — | — | Y640F (1.1) | |
| 291 | T-LGLL | D661Y | D661Y (2.5) | D661Y (3) | |
| 293 | T-LGLL | — | — | Y640F (2.5) | |
| Akita | 452 | Thymoma | — | F174V (1.9), S614R (8) | NT |
| 453 | Idiopathic | Y640F | D170G (6.4), Y640F (1.5) | NT | |
| 455 | T-LGLL | — | S614R (25.9) | NT | |
—, not detected; CD, Crohn's disease; NT, not tested; PB, peripheral blood; SjS, Sjögren syndrome; UPN, unique patient number.
*
The percentage of STAT3-mutated DNA, as determined by an allele-specific quantitative PCR.
†
CD8+ T cells were sorted from BM MNCs.