Table 1.
Characteristics of 176 participants of the GEMS imaging study
| Characteristics∗ | APOE ɛ4 allele noncarrier (N = 119)† | APOE ɛ4 allele carrier (N = 29) | Total (N = 176) |
|---|---|---|---|
| Sex, male | 73 (61) | 15 (52) | 105 (60) |
| Age, y | 85 (82, 91) | 84 (82, 89) | 85 (82, 91) |
| Education, y | 14 (10, 19) | 16 (12, 18) | 14 (11, 19) |
| Body mass index, kg/m2 | 26 (20, 34) | 25 (20, 30) | 26 (20, 34) |
| Smoking status‡ | |||
| Never | 48 (41) | 13 (45) | 70 (40) |
| Former | 67 (57) | 14 (48) | 99 (57) |
| Current | 3 (3) | 2 (7) | 6 (3) |
| Alcohol intake§, drinks/week | 0.5 (0, 21) | 1 (0, 14) | 0.5 (0, 15) |
| Race, white | 115 (97) | 29 (100) | 170 (97) |
| Total cholesterol, mg/dL | 167 (107, 241) | 175 (99, 264) | 166 (104, 242) |
| HDL cholesterol, mg/dL | 60 (41, 91) | 64 (41, 87) | 60 (39, 91) |
| Triglycerides‡, mg/dL | 98 (50, 203) | 96 (39, 241) | 96 (45, 219) |
| Systolic blood pressure, mm Hg | 126 (101, 163) | 122 (105, 164) | 124 (102, 161) |
| Diastolic blood pressure, mm Hg | 68 (50, 85) | 68 (57, 86) | 67 (51, 84) |
| History of cardiovascular disease | 42 (35) | 11 (38) | 63 (36) |
| History of diabetes§ | 6 (5) | 1 (4) | 8 (5) |
| Lipid-lowering medication use | |||
| Never user | 61 (51) | 13 (45) | 87 (49) |
| Former user | 11 (9) | 3 (10) | 18 (10) |
| Current use | 47 (40) | 13 (45) | 71 (40) |
| Antihypertensive treatment | |||
| Never user | 35 (29) | 8 (28) | 52 (30) |
| Former user | 4 (3) | 1 (3) | 6 (3) |
| Current use | 80 (67) | 20 (69) | 118 (67) |
| Mild cognitive impairment | 26 (22) | 7 (24) | 39 (22) |
| 3MSE | 98 (90, 100) | 98 (91, 100) | 98 (90, 100) |
| ß-amyloid deposition, SUVR | 1.6 (1.2, 2.6) | 2.1 (1.2, 2.8) | 1.6 (1.2, 2.6) |
| Hippocampal volume¶, % of ICV | 26 (21, 31) | 25 (20, 32) | 26 (20, 31) |
| White matter lesion volume¶, % of ICV | 0.7 (0.2, 2.1) | 0.7 (0.3, 2.5) | 0.8 (0.2, 2.3) |
Abbreviations: ICV, intracranial volume; 3MSE, Modified Mini-Mental State Examination score; SUVR, standardized uptake value ratio; HDLs, high-density lipoproteins; GEMS, Ginkgo Evaluation of Memory Study; APOE, apolipoproteins E.
∗
Values are median (Q5, Q95) or n (%).
†
N = 28 individuals with missing APOE genotype information were excluded.
‡
N = 175.
§
N = 174.
¶
N = 157.