Table 3.
Main Results of Pooled ORs and Analysis of C3 gene polymorphism with advanced AMD in our Meta-Analysis
| Subgroup | No. of studies | No. of patients | Allele model | Homozygote model | Heterozygote model | Dominant model | Recessive model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Control | OR(95% CI) | P | OR(95% CI) | P | OR(95% CI) | P | OR(95% CI) | P | OR(95% CI) | P | ||
| C3 rs2230199 (Associated allele vs. Reference allele: G vs. C) | |||||||||||||
| Overall | 36 | 34,805 | 29,499 | 1.49 (1.39,1.59) | < 0.001 | 2.33 (1.98,2.74) | < 0.001 | 1.53 (1.41,1.64) | < 0.001 | 1.62 (1.51,1.74) | < 0.001 | 1.99 (1.70,2.34) | < 0.001 |
| Caucasian | 28 | 31,372 | 26,130 | 1.48 (1.38,1.59) | < 0.001 | 2.20 (1.87,2.60) | < 0.001 | 1.55 (1.43,1.67) | < 0.001 | 1.63 (1.51,1.75) | < 0.001 | 1.88 (1.59,2.21) | < 0.001 |
| East Asian | 5 | 2122 | 2388 | 1.11 (0.56,2.20) | 0.76 | – | – | 1.32 (0.91,1.93) | 0.144 | 1.49 (1.04,2.15) | 0.032 | 5.60 (1.57,19.9) | – |
| Middle East | 3 | 1311 | 981 | 1.62 (1.33,1.97) | < 0.001 | – | – | 1.07 (0.66,1.73) | 0.798 | 1.49 (0.95,2.34) | 0.085 | 25.5 (3.35,194) | – |
| C3 rs1047286 (Associated allele vs. Reference allele: T vs. C) | |||||||||||||
| Overall | 13 | 16,232 | 16,222 | 1.45 (1.37,1.54) | < 0.001 | 2.06 (1.56,2.72) | < 0.001 | 1.72 (1.51,1.96) | < 0.001 | 1.76 (1.56,2.00) | < 0.001 | 1.71 (1.30,2.24) | < 0.001 |
| Caucasian | 10 | 14,688 | 14,548 | 1.45 (1.37,1.54) | < 0.001 | 2.06 (1.56,2.72) | < 0.001 | 1.72 (1.50,1.96) | < 0.001 | 1.76 (1.55,2.00) | < 0.001 | 1.71 (1.30,2.24) | < 0.001 |
| East Asian | 3 | 1544 | 1674 | 1.75 (0.49,6.29) | 0.388 | – | – | 2.06 (0.38,11.3) | 0.404 | 2.06 (0.38,11.3) | 0.404 | – | – |
| C3 rs2230205 (Associated allele vs. Reference allele: A vs. G) | |||||||||||||
| Overall | 5 | 3302 | 2732 | 0.99 (0.89,1.11) | 0.903 | 1.04 (0.77,1.42) | 0.780 | 1.00 (0.80,1.23) | 0.967 | 1.00 (0.81,1.22) | 0.992 | 1.06 (0.81,1.37) | 0.687 |
| Caucasian | 1 | 880 | 598 | 0.90 (0.66,1.23) | 0.507 | 0.45 (0.12,1.60) | 0.215 | 0.98 (0.69,1.39) | 0.902 | 0.93 (0.66,1.32) | 0.699 | 0.45 (0.13,1.60) | 0.217 |
| East Asian | 4 | 2422 | 2134 | 1.01 (0.89,1.14) | 0.903 | 1.10 (0.80,1.51) | 0.546 | 1.01 (0.77,1.32) | 0.967 | 1.04 (0.80,1.33) | 0.787 | 1.10 (0.84,1.43) | 0.497 |
| C3 rs2250656 (Associated allele vs. Reference allele: G vs. A) | |||||||||||||
| Overall | 5 | 3278 | 2632 | 0.90 (0.75,1.08) | 0.257 | 0.76 (0.49,1.16) | 0.207 | 0.78 (0.65,0.95) | 0.014 | 0.78 (0.65,0.94) | 0.010 | 0.83 (0.55,1.27) | 0.391 |
| Caucasian | 1 | 874 | 512 | 0.82 (0.64,1.05) | 0.117 | 0.77 (0.42,1.42) | 0.407 | 0.76 (0.55,1.05) | 0.097 | 0.76 (0.56,1.04) | 0.085 | 0.87 (0.48,1.57) | 0.642 |
| East Asian | 4 | 2404 | 2120 | 0.92 (0.73,1.16) | 0.486 | 0.74 (0.41,1.37) | 0.340 | 0.80 (0.63,1.02) | 0.068 | 0.79 (0.63,1.00) | 0.052 | 0.80 (0.44,1.45) | 0.456 |