Fig. 5.

H4K16Ac levels change less within the repressive TADs when MSL components are depleted. Boxplots show changes in H4K16Ac levels upon the RNAi-mediated knockdown of mof (a–b) or msl-2 (c–d). a, b Results from mof knockdown. c, d Results from msl-2 knockdown. e, f Changes in H4K16Ac as in A and B, but highly expressed genes within non-repressive TADs were filtered out to match their expression median to that of the repressive TAD genes as in Fig. 3. a, c, e, f Results from X-linked genes. b, d Results from autosomal genes