Table 3.

Spectra of mutations detected in the supF gene (experiment 1)^a

	G	GO	THF
point mutations at position 122
G:C - > A:Tb	0 (0)	0 (0)	0 (0)
G:C - > T:Ac	3 (10)	23 (46)	9 (15)
G:C - > C:Gd	0 (0)	8 (16)	11 (18)
deletion	0 (0)	1 (2)	11 (18)
mutations at other positions
transition
A:T - > G:C	1 (3)	0 (0)	0 (0)
G:C - > A:T	16 (53)	8 (16)	17 (28)
transversion
A:T - > T:A	0 (0)	0 (0)	0 (0)
A:T - > C:G	3 (10)	2 (4)	0 (0)
G:C - > T:A	9 (30)	6 (12)	11 (18)
G:C - > C:G	4 (13)	4 (8)	19 (32)
small insertion (1–2 bp)	1 (3)	1 (2)	0 (0)
large insertion (> 2 bp)	6 (20)	1 (2)	1 (2)
small deletion (1–2 bp)	0 (0)	0 (0)	1 (2)
large deletion (> 2 bp)	12 (40)	8 (16)	12 (20)
others	0 (0)	0 (0)	2 (3)e
total mutations	55	62	94
total colonies analyzed	30 (100)	50 (100)	60 (100)

^aAll data are represented as cases found (%)

^bThe mutation corresponds to incorporation of TMP opposite G/G^O/THF

^cThe mutation corresponds to incorporation of dAMP opposite G/G^O/THF

^dThe mutation corresponds to incorporation of dGMP opposite G/G^O/THF

^eGG - > T at positions 121–122 and G - > AAGA at position 122