Table 8.
Number and proportion (%) of Swedish Lynch syndrome family members with onset of primary cancer < 50 years age in relation to gender and MMR gene mutation
| CRC No. (%) |
EC No (%) |
OVC No. (%) |
UTC No. (%) |
GC No. (%) |
SB No. (%) |
NMS No. (%) |
|
|---|---|---|---|---|---|---|---|
| Male | 203 (54) | NA | NA | 8 (27) | 7 (22) | 3 (38) | 5 (42) |
| Female | 139 (51) | 92 (45) | 28 (64) | 9 (26) | 7 (27) | 2 (25) | 1 (6) |
| MLH1 | 192 (62) | 33 (50) | 5 (63) | 3 (19) | 5 (25) | 2 (25) | 1 (13) |
| MSH2 | 119 (54) | 50 (59) | 16 (80) | 14 (34) | 6 (20) | 3(39) | 5 (27) |
| MSH6 | 23 (26) | 9 (19) | 6 (42) | – | 4 (67) | – | – |
| PMS2 | 8 (30) | – | – | – | – | – | – |
Calculation based on the group of patients with verified age at diagnosis and not on the entire cohort
CRC Colorectal cancer, EC Endometrial cancer, OC Ovarian cancer, UTC Urinary tract cancer (excluding prostate cancer), GC Gastric cancer, SB Small bowel cancer, NMS non-melanoma skin cancer