Table 2.

Distribution of the methylated adenosine in DNA and RNA.

Species	DNA m6dA distribution	Functions
D. melanogaster	Transposons, intergenic regions, nucleosomal biased, preferential for repeat sequences	Promotion of transposon expression
		Repression of many genes involved in CNS functions
		Promote GSC differentiation
C. reinhardtii	TSS of more than 14,000 genes actively	Mainly promote gene transcription
	Linker DNA biased
	Intergenic regions
C. elegans	No preference in the genome	Mainly promote gene transcription
	Nucleosomal biased
T. thermophilus	5′ end of the gene body	Enhance transcription of the genes bearing m6dA sites
	AT motif of the linker DNA regions flanked by nucleosomes particularly
	H2A.Z-containing nucleosomes associated with Pol II-transcribed genes
Danio rerio	Preferential for repeat sequences
Xenio laevis	Depleted at TSSs
Mus musculus	Depleted at TSSs, enriched on LINE-1 in ESC	Epigenetic silencing of LINE-1 and surrounding
	Varies in accordance with physiological conditions	Enhancers and genes
		Involved in ESC self-renewal and differentiation
Homo sapiens	Depleted at TSSs, enriched on LINE-1	Similar to mouse
Species	RNA m6A	Biological functions
Mammals	5′UTR and 3′UTR	Regulation of gene expression
	Stop codon	RNA metabolism including mRNA, rRNA, tRNA, miRNA, snoRNA, and circRNA
	Low abundance in coding regions long introns
		Determination of cell fate