Table 2.

Gene ontology analysis of differentially expressed genes associated with glioma.

Expression	Category	Term	Count	Ratio (%)	p value	FDR
Upregulated	GOTERM_BP_FAT	GO:0000278_mitotic cell cycle	105	15.21739	1.34E − 26	2.60E − 23
	GOTERM_BP_FAT	GO:1903047_mitotic cell cycle process	100	14.49275	1.81E − 26	3.51E − 23
	GOTERM_BP_FAT	GO:0022402_cell cycle process	120	17.3913	1.00E − 22	1.94E − 19
	GOTERM_BP_FAT	GO:0007067_mitotic nuclear division	62	8.985507	1.10E − 21	2.14E − 18
	GOTERM_BP_FAT	GO:0051301_cell division	71	10.28986	5.72E − 21	1.11E − 17
	GOTERM_MF_FAT	GO:0005201_extracellular matrix structural constituent	15	2.173913	2.78E − 07	4.37E − 04
	GOTERM_MF_FAT	GO:0015026_coreceptor activity	9	1.304348	2.11E − 05	3.32E − 02
	GOTERM_MF_FAT	GO:0017147_Wnt protein binding	8	1.15942	4.31E − 05	6.79E − 02
	GOTERM_MF_FAT	GO:0003777_microtubule motor activity	12	1.73913	4.41E − 05	6.93E − 02
	GOTERM_MF_FAT	GO:0019838_growth factor binding	15	2.173913	5.77E − 05	9.08E − 02
	GOTERM_CC_FAT	GO:0044420_extracellular matrix component	36	5.217391	1.74E − 21	2.56E − 18
	GOTERM_CC_FAT	GO:0005578_proteinaceous extracellular matrix	55	7.971014	3.38E − 19	4.99E − 16
	GOTERM_CC_FAT	GO:0031012_extracellular matrix	65	9.42029	1.05E − 17	1.54E − 14
	GOTERM_CC_FAT	GO:0005604_basement membrane	26	3.768116	3.08E − 15	4.59E − 12
	GOTERM_CC_FAT	GO:0015630_microtubule cytoskeleton	93	13.47826	2.04E − 14	3.01E − 11
Downregulated	GOTERM_BP_FAT	GO:0099536_synaptic signaling	194	15.39683	1.23E − 90	2.39E − 87
	GOTERM_BP_FAT	GO:0098916_anterograde trans-synaptic signaling	194	15.39683	1.23E − 90	2.39E − 87
	GOTERM_BP_FAT	GO:0099537_trans-synaptic signaling	194	15.39683	1.23E − 90	2.39E − 87
	GOTERM_BP_FAT	GO:0007268_chemical synaptic transmission	194	15.39683	1.23E − 90	2.39E − 87
	GOTERM_BP_FAT	GO:0007399_nervous system development	324	25.71429	2.19E − 60	4.25E − 57
	GOTERM_MF_FAT	GO:0022836_gated channel activity	95	7.539683	1.44E − 38	2.37E − 35
	GOTERM_MF_FAT	GO:0005216_ion channel activity	101	8.015873	2.22E − 33	3.67E − 30
	GOTERM_MF_FAT	GO:0022838_substrate-specific channel activity	101	8.015873	5.72E − 32	9.44E − 29
	GOTERM_MF_FAT	GO:0015267_channel activity	103	8.174603	1.31E − 30	2.16E − 27
	GOTERM_MF_FAT	GO:0022803_passive transmembrane transporter activity	103	8.174603	1.57E − 30	2.59E − 27
	GOTERM_CC_FAT	GO:0045202_synapse	232	18.4127	9.60E − 105	1.43E − 101
	GOTERM_CC_FAT	GO:0097458_neuron part	306	24.28571	1.50E − 104	2.23E − 101
	GOTERM_CC_FAT	GO:0044456_synapse part	202	16.03175	2.51E − 97	3.73E − 94
	GOTERM_CC_FAT	GO:0043005_neuron projection	232	18.4127	1.87E − 80	2.79E − 77
	GOTERM_CC_FAT	GO:0030424_axon	131	10.39683	4.44E − 58	6.61E − 55

GO: gene ontology; BP: biological process; MF: molecular function; CC: cell component; FDR: false discovery rate.