Figure 3.

Schematic diagram of the pathway classification and gene enrichment of differentially expressed mRNAs (DEmRNAs) in the sciatic nerve of 12-month-old and 1-week-old Sprague Dawley rats.

(A) Kyoto Encyclopedia of Genes and Genomes (KEGG) classification: Orange columns represent cellular process; brown columns represent environmental information processing; green columns represent genetic information processing; blue columns represent metabolism; and purple columns represent organismal systems. (B) KEGG pathway enrichment: The area of the circles represents the number of DEmRNAs involved in the pathway. Different colors indicate different Q-values of DEmRNAs in the pathway between adult rats and young rats. Green represents Q > 0.15; yellow represents Q > 0.10 and Q < 0.15; orange represents Q < 0.10 and Q > 0.05; and red represents Q < 0.05. The standard of the test was set as 0.05 (n = 4 per group).