Table 1.

Inclusion and exclusion criteria used in the review of available literature

Inclusion criteria	Exclusion criteria
Publications were included that	Publications were excluded that
• Discussed the clinical application of inhaled methoxyflurane at analgesic doses in pain or medical procedures • Related solely to the treatment of trauma pain in specific patient groups including pediatrics, elderly • Related to the treatment patterns and pain management of moderate to severe trauma pain • Explored the safety or inhaled analgesic methoxyflurane with respect to health and safety of healthcare workers and patients	• Discussed the use of inhaled methoxyflurane at anesthetic dosing • Were not conducted in patients or were not focused on human data • Did not report on pain or treatment for pain (emergency or procedural) • Focused on long-term or chronic pain • Focused on the treatment of pain in major trauma • Related solely to patients whose treatment would be outside the legal licensed indication for inhaled analgesic methoxyflurane including pregnant patients or patients with reduced consciousness