Fig 3.

(a) Hysteresis collapse over time in the presence of noise. A dose-response curve for the same two-well system with additive noise is constructed after varying numbers of time steps, 100 (green curve), 1000 (red curve), or 10 000 (blue curve). The only difference between these dose-response curves is the speed with which the ramps are performed; the model there has no pharmacokinetic equilibration time and concentrations can be changed instantaneously. (b) Effect of noise on hysteresis collapse over time. The same simulation was run for high (black) or low (white) levels of noise, and the resulting $\Delta E{C}_{50}$ estimates are plotted as a function of delay time. Higher levels of noise result in a shorter mixing time with faster collapse of hysteresis.