Fig 3.

Degree of conditioned-pain-modulation effect after at least 20 s conditioning stimulus in extremely preterm (EP) and term-born control (TC) males and females. (a) The percentage change in pressure pain threshold (PPT) during the conditioning stimulus is not significantly different across groups based on EP status or sex. Individual data points, bars=mean [95% confidence interval (CI)]. (b) Raised PPT during the conditioning stimulus (15 s) is maintained at 50 and 90 s. Data points=mean (95% CI); ***P<0.001; **P<0.01 all groups increase vs baseline; #P<0.05 TC males, EP females, and EP males vs baseline; two-way repeated measures analysis of variance with Bonferroni post hoc comparisons.