Fig 4. Maternal transmission of the PM allele in Exo1^+/+ and Exo1^A/A mice.

Statistical analysis of the data shown in this figure is described in the Material and Methods section. A) Proportion of alleles that were larger, smaller or the same size as the parental alleles in the progeny of 2–6 months old Exo1^+/+ and Exo1^A/A females with 165–175 repeats. 55 pups from 7 Exo1^+/+ and 35 pups from 5 Exo1^A/A females were analyzed. B) Distribution of the change in the repeat number in the progeny of the mothers shown in panel A. The mean number of repeats added to the PM allele in the progeny of Exo1^A/A mice was 12.5 compared to 9.3 in the progeny of Exo1^+/+ mice (p < 0.0001).