Table 1. Analysis of H3K36Me3 expression with various clinicopathological features in 152pateints with surgically resectable primary hepatocellular carcinoma.

		H3K36Me3 expression
Variables		Total	No n(%)	Yes n (%)	O.R. (95% C.I.)	P value
Age	≤ 56	77	21	56 (72.7)	1.0
	> 56	75	27	48 (64.0)	1.32 (0.65–2.67)	0.4039
Gender	Male	122	41	81 (66.4)	1.0
	Female	30	7	23 (76.7)	1.66 (0.61–4.67)	0.2781
HBsAg	(—)	41	15	26 (63.4)	1.0
	(+)	111	33	78 (70.3)	1.36 (0.60–3.099)	0.4197
Anti-HCV	(—)	100	30	70 (70.0)	1.0
	(+)	39	15	24 (61.5)	0.697 (0.30–1.60)	0.3381
AFP (ng/ml)	≤ 200	74	30	42 (56.8)	1.0
	> 200	78	18	60 (76.9)	2.38 (1.11–5.13)	0.0148
Cirrhosis	(—)	105	32	73 (69.5)	1.0
	(+)	47	16	31 (66.0)	0.85 (0.38–1.89)	0.6620
Tumor size (cm)	≤ 5	62	25	37 (60.0)	1.0
	> 5	90	23	67 (74.4)	1.97 (0.93–4.18)	0.0542
Tumor grade	I-II	96	39	57 (59.4)	1.0
	III-IV	56	9	47 (83.9)	3.57 (1.48–8.86)	0.0017
Tumor stage	I	56	27	29 (51.8)	1.0
	II-III	96	21	75 (78.1)	3.08 (1.54–7.24)	0.0008
p53 mutation	(—)	64	22	42 (65.6)	1.0
	(+)	55	17	38 (69.1)	1.17 (0.51–2.72)	0.6880
β-catenin mutation	(-)	113	37	76 (67.3)	1.0
	(+)	14	5	9 (64.3)	0.88 (0.24–3.27)	0.9376
CK19	(-)	87	40	47 (54.0)	1.0
	(+)	56	6	50 (89.3)	7.09 (2.57–20.59)	< 0.0001
HNF1β	(-)	45	23	22 (48.9)	1.0
	(+)	70	14	56 (80.0)	4.18 (1.48–4.42)	0.0005

Abbreviations: O.R., Odds ratio; C.I., Confidence interval; AFP, α-fetoprotein; CK19, cytokeratin 19

HNF1β, hepatocyte nuclear factor 1β.

(-) designates absence; (+) designates presence.