Table 2. Multivariate analyses of the risk factors associated with tumor grade, tumor stage, and survival of the patients with surgically resectable primary hepatocellular carcinoma.
| Covariate | Coefficient | S.E. | Z-Statistic | O.R./H.R. (95% C.I.) | P value |
|---|---|---|---|---|---|
| Grade* | |||||
| Age (L/H) | -0.8925 | 0.5072 | -1.7598 | 0.0496 (0.1516–1.1069) | 0.0784 |
| Gender (M/F) | -0.9709 | 0.6295 | -1.5423 | 0.3787 (0.1103–1.3008) | 0.1230 |
| Serum HBsAg (P/N) | 2.0003 | 0.7222 | 2.7697 | 7.3914 (1.7947–30.4417) | 0.0056 |
| Anti-HCV (P/N) | 0.7637 | 0.6219 | 1.2280 | 2.1462 (0.6343–7.2619) | 0.2195 |
| AFP (L/H) | -0.3774 | 0.5289 | -0.7134 | 0.6857 (0.2432–1.9336) | 0.4756 |
| Cirrhosis (N/Y) | -0.4044 | 0.6150 | -0.6576 | 0.6674 (0.2000–2.2276) | 0.5108 |
| Tumor Size (S/L) | -1.0687 | 0.5610 | -1.9050 | 0.3434 (0.1144–1.0313) | 0.0568 |
| p53 mutation (P/N) | 0.7167 | 0.4992 | 1.4356 | 2.0476 (0.7697–5.4473) | 0.1511 |
| β-catenin mutation (P/N) | 0.2930 | 0.8103 | 0.3616 | 1.3404 (0.2739–6.5604) | 0.7177 |
| H3K36me3 expression (P/N) | 1.0678 | 0.5388 | 1.9819 | 2.9091 (1.0119–8.3633) | 0.0475 |
| Stage* | |||||
| Age (L/H) | 1.0659 | 0.6097 | 1.7483 | 2.9034 (0.8790–9.5904) | 0.0804 |
| Gender (M/F) | 1.0687 | 0.7811 | 1.3682 | 2.9116 (0.6299–13.4586) | 0.1712 |
| Serum HBsAg (P/N) | -0.4054 | 0.7423 | -0.5461 | 0.6667 (0.1556–2.8563) | 0.5850 |
| Anti-HCV (P/N) | -0.7226 | 0.7369 | -0.9806 | 0.4855 (0.1145–2.0579) | 0.3268 |
| AFP (L/H) | -1.8610 | 0.6279 | -2.9636 | 0.1555 (0.0454–0.5325) | 0.0030 |
| Cirrhosis (N/Y) | -0.7414 | 0.7624 | -0.9724 | 0.4764 (0.1069–2.1232) | 0.3308 |
| Tumor Size (S/L) | -1.1781 | 0.6218 | -1.8948 | 0.3079 (0.0910–1.0414) | 0.0581 |
| Grade (L/H) | -0.9166 | 0.6440 | -1.4233 | 0.3999 (0.1132–1.4129) | 0.1547 |
| p53 mutation (P/N) | 1.1467 | 0.6311 | 1.8170 | 3.1479 (0.9137–10.8444) | 0.0692 |
| β-catenin mutation (P/N) | -2.0414 | 0.9311 | -2.1926 | 0.1298 (0.0209–0.8053) | 0.0283 |
| H3K36me3 expression (P/N) | 1.5274 | 0.6034 | 205312 | 4.6064 (1.4116–15.0317) | 0.0114 |
| Survival time‡ | |||||
| Age (L/H) | 0.0674 | 0.2709 | 0.2489 | 1.0698 (0.6290–1.8193) | 0.8034 |
| Gender (M/F) | -0.3836 | 0.3105 | -1.2357 | 0.6814 (0.3708–1.2521) | 0.2166 |
| Serum HBsAg (P/N) | -0.2593 | 0.3686 | -0.7036 | 0.7716 (0.3747–1.5889) | 0.4817 |
| Anti-HCV (P/N) | 0.4520 | 0.3362 | 1.3445 | 1.5714 (0.8131–3.0368) | 0.1788 |
| AFP (L/H) | 0.1640 | 0.2927 | 0.5602 | 1.1782 (0.6638–2.0911) | 0.5753 |
| Cirrhosis (N/Y) | -1.6301 | 0.3714 | -4.3888 | 0.1959 (0.0946–0.4057) | <0.0001 |
| Tumor Size (S/L) | -1.3648 | 0.3704 | -3.6846 | 0.2554 (0.1236–0.5279) | 0.0002 |
| Grade (L/H) | -0.1916 | 0.2958 | -0.6478 | 0.8256 (0.4624–1.4742) | 0.5171 |
| Stage (L/H) | 1.8254 | 0.3787 | 4.8205 | 6.2056 (2.9542–13.0353) | <0.0001 |
| p53 mutation (P/N) | -0.1376 | 0.2648 | -0.5195 | 0.8715 (0.5186–1.4644) | 0.6034 |
| β-catenin mutation (P/N) | -0.2002 | 0.4831 | -0.4145 | 0.8185 (0.3176–2.1097) | 0.6785 |
| H3K36me3 expression (P/N) | -0.3380 | 0.2889 | -0.1170 | 0.7132 (0.4048–1.2564) | 0.2420 |
Abbreviations: S.E., Standard error; O.R., Odds ratio; H.R., Hazard ratio; C.I., Confidence interval; M, male; F, female; AFP, α-fetoprotein; H3K36me3,trimethylation of histone H3K36; L, low or large; H, high; P, presence; N, absences or no; Y, yes; S, small.
*Logistic regression model
‡Cox’s proportional hazards model