Table 2.
The haplotypes association analysis of three SNPs in TBX6 investigated in 161 CS cases and 166 controls
|
Haplotype |
Before corrected | Corrected | ||||||
|---|---|---|---|---|---|---|---|---|
| Frequency in case | Frequency in control | OR with 95% CI | p | Frequency in case | Frequency in control | OR with 95% CI | p | |
| T-C-A | 0.550 | 0.482 | 1.418 (1.021-1.969) | 0.038 | 0.512 | 0.482 | 1.322 (0.950-1.840) | 0.110 |
| T-C-C | 0.003 | 0.009 | 0.427 (0.044-4.164) | 0.635 | ||||
| T-T-A | 0.006 | 0.000 | 2.282 (1.984-2.625) | 0.195 | ||||
| T-T-C | 0.012 | 0.000 | 2.282 (1.984–2.625) | 0.039 | ||||
| C-C-A | 0.025 | 0.003 | 10.255 (1.264-83.219) | 0.013 | ||||
| C-C-C | 0.006 | 0.000 | 2.282 (1.984-2.625) | 0.195 | ||||
| C-T-A | 0.056 | 0.081 | 0.855 (0.448-1.631) | 0.744 | ||||
| C-T-C | 0.342 | 0.425 | 1 | -- | 0.340 | 0.424 | 1 | -- |
The haplotypes of case and control groups were compared using Pearson χ2 test (two-sided). Wild-type/mutation: C/T in rs2289292, T/C in rs3809624 and C/A in rs3809627.
Abbreviation: SNP, single nucleotide polymorphisms; CS, congenital scoliosis; OR, odds ratio; CI, confidence interval.