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. Author manuscript; available in PMC: 2018 Oct 24.
Published in final edited form as: Cell Physiol Biochem. 2017 Nov 23;44(2):701–715. doi: 10.1159/000485284

Fig. 1.

Fig. 1.

Effects of Y-27632 on the blood pressure and aortic stiffness in SHR and WKY rats. (A-B) Time dependent changes of systolic blood pressure (SBP) (A) and diastolic blood pressure (DBP) (B) measured by tail cuff at conscious status. (C) Representative waveform of aortic blood pressure measured invasively by a Millar catheter at the end of two-week treatment. (D) Systolic Aortic blood pressure (SAP), diastolic blood pressure (DAP) and pulse pressure (PP) under the treatments. (E) Reduction rate of blood pressure versus vehicle control. (F-G) Aortic stiffness in SHR and WKY rats in vivo evaluated by echography before (D0) or at day 7 (D7) and day 14 (D14) after the initiation of the treatments with Y-27632 or vehicle (DMSO), reflected by the change of arterial com-pliance (F) and arterial strain (G). Data are shown as mean ± SEM, *P<0.01 vs. corresponding WKY. #P<0.05, ##P< 0.01 vs corresponding vehicle. n= 5 rats/group.