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. Author manuscript; available in PMC: 2018 Oct 24.
Published in final edited form as: Cell Physiol Biochem. 2017 Nov 23;44(2):701–715. doi: 10.1159/000485284

Fig. 2.

Fig. 2.

Effect of Y-27632 on TA VSMC stiffness. (A) Thickness of medial layer of aortic wall and the ratio of lumen diameter. (B) Collagen deposition in medial layer of aortic wall. Scale bar: 100μm, n = 5 rats/group. (C) Representative force curves during advance from atomic force microscopy (AFM) nanoindentation of vascular smooth muscle cells (VSMCs) from the thoracic aorta (TA). (D) Representative of the reversible changes of elastic modulus with or without the presence of Y-27632 in SHR TA VSMC. (E) Representative dose response of SHR TA VSMC stiffness to Y-27632. (F) Average apparent elastic modulus of TA VSMCs. n= 4 rats/group. Data are shown as mean ± SEM, *P<0.01 vs. corresponding WKY. #P<0.05, ##P< 0.01 vs corresponding vehicle. NS: no significant difference.