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. 2018 Oct 24;4(10):eaat2166. doi: 10.1126/sciadv.aat2166

Fig. 1. Phylogenetic separation of bryophytes and angiosperms and convergent evolution of the tetrahydrocannabinoid scaffold in (−)-trans-THC and (−)-cis-PET.

Fig. 1

Both cannabinoids act as partial agonists on CB1 receptors in vitro and in vivo. Ma, mega-annum. Photo credit: S. Fischer (D-CHAB, LOC, ETH Zurich).