Fig. 4. CB1 receptor dependence of the pharmacological effects of Δ9-trans-THC and PET diastereoisomers in mice.
(A) Hypothermia, (B) catalepsy, (C) hypolocomotion, and (D) analgesia elicited by Δ9-trans-THC (red), cis-PET (green), and trans-PET (blue) compared with vehicle control (white) in BALB/c male mice 1 hour after intraperitoneal injection. The pharmacological effects were fully blocked by the CB1 receptor antagonist rimonabant (SR1, gray columns). Doses are expressed in mg/kg. Data show means ± SD. Groups were compared with the vehicle-treated control group using a one-way analysis of variance (ANOVA) following Tukey’s post hoc test, n = 5 to 15 mice per group. ***P < 0.001, **P < 0.01, *P < 0.05 versus vehicle or as reported by the arches.