Fig. 6. Effects of cis-PET and Δ⁹-trans-THC on a panel of 44 CNS targets (GPCRs, ion channels, nuclear receptors, membrane transporters, and enzymes).

Data show the percentage of binding or protein activity (enzyme, transporter, and ion channels) at test concentrations of 10 μM (cis-PET, blue line) and 1 μM (cis-PET, orange line; Δ⁹-trans-THC, green line). Data presented are obtained from two independent experiments each performed in duplicate. For full names of abbreviations, see the Supplementary Materials. The 100% is intended as full enzymatic activity (enzymes), substrate transport (membrane transporter), receptor binding (GPCRs and nuclear receptors), and ion permeability (ion channels). The percentage is expressed as positive or negative values based on an increase or reduction of the target protein.