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Scheme demonstrating the basic design flow of a TIMS funnel (top) and the application of TIMS technology to resolve a peptide modified by two isobaric PTMs (bot-tom). The application of TIMS separation to co-eluting pep-tides, or modified peptides, would enable the identification of each peptide species when compared with a standard. For example, a peptide modified by lysine-propionyl (t1) or lysine-acrolein (t2) could potentially be resolved.
