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Proton RBE for clonogenic cell survival as a function of LETd at 2 Gy photon dose for tissue (α/β)x of 2 Gy (solid) and 10 Gy (dashed) as predicted by an empirical model [27]. The grey area shows the clinically and dosimetrically most relevant region as LET values are typically between 2.5 and 13 keV/μm [16]. Abbreviations: LET, linear energy transfer; LETd, dose-averaged LET; RBE, relative biological effectiveness.
