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Proton RBE for clonogenic cell survival as a function of dose for an LETd of 2.5 keV/μm for tissue (α/β)x of 2 Gy (solid) and 10 Gy (dashed) as predicted by an empirical model [27]. The grey area shows the clinically most relevant region for standard fractionation with doses at 2 Gy and doses to organs at risk <2Gy. Abbreviations: LETd, dose-averaged linear energy transfer; RBE, relative biological effectiveness.
