Table 1.
EKG intervals, Ex Vivo and In Vivo Programmed Electrical Stimulation EKG Intervals
| EKG Intervals | ||
| Control | Wnt LOF | |
| Conscious HR (bpm) | 692 ± 16 | 718 ± 12 |
| Isoflurane HR (bpm) | 488 ± 15 | 497 ± 23 |
| P wave duration (msec) | 12.5 ± 1.3 | 10.5 ± 0.7 |
| PR (msec) | 37.7 ± 0.8 | 34.5 ± 0.7* |
| QRS (msec) | 10.3 ± 0.7 | 10.1 ± 0.4 |
| QT (msec) | 17.5 ± 0.9 | 17.8 ± 8 |
| Ex Vivo Programmed Electrical Stimulation | ||
| Control | Wnt LOF | |
| Mice with VT following RV stim | 0/7 | 5/7* |
| Mice with VT following LV stim | 0/7 | 0/7 |
| Duration VT (s) | N/A | 94 ± 50 |
| VT cycle length (msec) | N/A | 48 ± 3 |
| Mice with spontaneous NSVT/VT | 0/7 | 2/7 |
| Total episodes spontaneous NSVT/VT | 0 | 734 |
| In Vivo Programmed Electrical Stimulation | ||
| Control | Wnt LOF | |
| Heart Rate (bpm) | 521 ± 21 | 572 ± 45 |
| V to A 1:1 (msec) | 90 ± 6 | 96 ± 6 |
| V to A Wenckebach (msec) | 83 ± 5 | 88 ± 5 |
| RVERP120 (msec) | 38 ± 3 | 28 ± 3* |
| Episodes NSVT/VT (S1S2) | 0 | 10* |
| Total episodes NSVT/VT | 0 | 31* |