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. 2018 Oct 5;97(40):e12441. doi: 10.1097/MD.0000000000012441

Figure 4.

Figure 4

99mTc-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2) single-photon emission computed tomography/computed tomography (SPECT/CT) images (axial) and color Doppler flow imaging (CDFI) images before PB, and at 3 and 6 months post-PB treatment in a 55-year-old woman with choroidal melanoma (CM) (patient 6). Uptake of 99mTc-3PRGD2 in the lesion in the left eye (red cross) fell from tumor-to-occipital bone ratio (T/O) = 1.34 before PB to T/O = 0.97 at 3 months post-PB. Follow-up 99mTc-3PRGD2 imaging at 6 months post-PB showed increased accumulation, with T/O = 1.68. B-mode ultrasonography and CDFI showed tumor sizes of 9.5 × 3.2, 8.6 × 3.2, and 14.3 × 9.1 mm before treatment and at 3 and 6 months post-PB, respectively. Enucleation was done at 8 months after PB. Unfortunately, liver metastasis was detected at about 21 months post-PB. However, this information was acquired by phone interview and no liver metastasis images were available because the patient was not a resident of Peking. CDFI = color Doppler flow imaging, CT = computed tomography, PB = plaque brachytherapy.