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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Immunol. 2018 Sep 28;201(9):2767–2775. doi: 10.4049/jimmunol.1701195

Figure 6. Dectin-1 signaling pathways in IL-1β production.

Figure 6.

A,B: IL-1β production by bone marrow neutrophils from C57BL/6 and Dectin-1−/− mice stimulated with Aspergillus swollen conidia and examined by ELISA (A) and Western blot analysis (B). C,D. IL-1β production by bone marrow neutrophils (C) or bone marrow derived macrophages (D) from C57BL/6 mice following incubation with Aspergillus swollen conidia in the presence of p-Syk inhibitor R406 or the Raf-1 kinase inhibitor GW5074. E. IL-1β cleavage and cell signaling in C57BL/6 bone marrow neutrophils from mice incubated with Aspergillus and either R406 or GW5074. F,G. IL-1β and CXCL2 production by neutrophils from C57BL/6 mice and incubated with MEKK inhibitor U0126 or JNK inhibitor SP600125. H. LDH release from bone marrow neutrophils compared with bone marrow derived macrophages incubated with Aspergillus swollen conidia. Experiments were repeated twice with similar results.