Table 3-2 Pretreatment condition 2.

a. Total
	Temperature ≧38°C		Blood test								Hemodynamics								Infection&
	(−)	(+)	WBC		CRP		Alb		Cr		ABI		TBI		SPP		Toe pressure		Local (foot)				Systemic
			n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	Uninfected	Skin or subcutaneous tissue (erythema)*		Deep tissue#	SIRS$
																				≦2.0 cm	>2.0 cm		(+)	(−)
Rutherford 4	232	9	230	6,725	214	0.55	215	3.6	229	1.08	121	0.56	8	0.41	86	20	8	51.5	217	12	5	7	5	237
Rutherford 5	688	39	710	7,300	690	1.00	669	3.4	712	2.28	463	0.61	31	0.26	432	22	31	36	480	168	50	33	19	709
Rutherford 6	143	27	169	8,600	169	4.62	161	2.9	169	1.90	79	0.66	3	0.18	92	22.5	3	27	50	31	36	54	16	154
Total	1,063	75	1,109	7,400	1,073	1.16	1,045	3.4	1,110	1.54	663	0.61	42	0.27	610	22	42	36	747	211	91	94	40	1,100
b. ASO
	Temperature ≧38°C		Blood test								Hemodynamics								Infection&
	(−)	(+)	WBC		CRP		Alb		Cr		ABI		TBI		SPP		Toe pressure		Local (foot)				Systemic
			n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	n	Median	Uninfected	Skin or subcutaneous tissue (erythema)*		Deep tissue#	SIRS$
																				≦2.0 cm	>2.0 cm		(+)	(−)
Rutherford 4	227	9	225	6,700	209	0.54	210	3.6	224	1.09	119	0.55	8	0.41	83	20	8	51.5	213	11	5	7	5	232
Rutherford 5	673	37	694	7,300	675	1.00	654	3.4	696	2.78	452	0.61	30	0.25	427	22	30	36	467	166	50	30	17	694
Rutherford 6	142	26	167	8,550	167	4.62	159	2.9	167	1.94	78	0.66	3	0.18	91	22	3	27	50	31	34	54	16	152
Total	1,042	72	1,086	7,375	1,051	1.17	1,023	3.4	1,087	1.61	649	0.60	41	0.26	601	22	41	36	730	208	89	91	38	1,078

WBC: white blood cell, CRP: C reactive protein, Alb: albumin, Cr: creatinine, ABI: ankle brachial (pressure) index, TBI: toe brachial (pressure) index, SPP: skin perfusion pressure, SIRS: systemic inflammatory response syndrome ^& Presence of infection is defined by the presence of at least 2 of the following items: ①Local swelling or induration, ②Erythema >0.5 to ≦2 cm around the ulcer, ③Local tenderness or pain, ④Local warmth, ⑤Purulent discharge (thick, opaque to white, or sanguineous secretion). * Local infection at skin and subcutaneous tissue was classified by the spreading of erythema (≦2.0 cm or >2 cm) around the ulcer/gangrene. ^# Local infection involving structures deeper than skin and subcutaneous tissues (e.g., abscess, osteomyelitis, septic arthritis, fasciitis). ^$ The signs of SIRS are manifested by two or more of the following: ①Temperature >38 or <36°C, ②Heart rate >90 beats/min, ③Respiratory rate >20 breaths/min or PaCO₂ <32 mmHg, ④White blood cell count >12,000 or <4,000 cu/mm or 10% immature (band) forms.