Table 4.

Model-based tobacco outcome measures and adjusted rate ratios (1 gram increase in average daily cannabis) separated by low and moderate/high baseline nicotine dependence levels for the entire cigarette smoking sub-sample (n=117).

Outcome	Cohort	Rate Ratio (95% CI) ^ǂ (1 Gram Increase in Avg. Cannabis Use)
Weekly Outcomes Measured During Treatment

	Overall	*1.10 (1.06–1.14)*
Cigarette Smoking Days	Low FTND	*1.18 (1.10–1.26)*
	High FTND	1.03 (0.99–1.06)
	Overall	*1.05 (1.01–1.09)*
Cigarettes Per Day	Low FTND	*1.16 (1.07–1.25)*
	High FTND	1.04 (1.00–1.08)

^ǂ

The rate ratio (RR) represents the increased risk of greater tobacco use rates per week for a 1 gram increase in self-reported cannabis use amounts and is derived from the Poisson regression model. RR results are shown adjusted for study treatment (NAC or PBO), study visit, baseline nicotine dependence level, race, and concurrent cannabis use. In the final models for cigarette smoking days, site and site x treatment covariate effects were insignificant, thus site was included in the model as a random effect. In the final models for cigarettes per day, site was a significant predictor of CPD and was retained in the model as a covariate.

p<0.05