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Opposite phenotypes observed in the S421 phospho-dead and phospho-mimic knockin mice.
| Phenotypic assays | S421A knockin mice (Li et al, 2011) | S421E knockin mice (this study) |
|---|---|---|
| Contextual Fear Memory | Increased | Decreased (Fig. 1c) |
| Synaptic scaling up | Normal | Reduced (Fig. 2) |
| Synaptic scaling down | Lost | Normal (Fig. 2) |
| Excitatory synaptogenesis | Increased | Decreased (Fig. 1d) |
