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Opposite phenotypes observed in the S421 phospho-dead and S80A phospho-dead knockin mice.
| Phenotypic assays | S421A knockin mice (Li et al, 2011 and 2014; Tao et al, 2009) | S80A knockin mice (this study and Tao et al, 2009) |
|---|---|---|
| Morris water maze | Enhanced | Impaired (Fig. 3) |
| Baseline locomotor activity | Increased | Decreased |
| aNPC proliferation | Decreased | Increased (Fig. 4a) |
| aNPC neural differentiation | Increased | Decreased (Fig. 4b) |
| MeCP2 binding to gene promoters | Increased | Decreased |
