Table 3. Subgroup analyses between ADAMTS14/rs4747096 gene polymorphism and the risk of KOA.
Variables | rs4747096 (Case/control) | GG compared with AA | GG compared with AG | GG/AG compared with AA | GG compared with AG/AA | G compared with A | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AG | GG | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |
Sex | |||||||||||||
Male | 73/132 | 63/96 | 34/20 | 3.07 (1.65–5.73) | 0.020 | 2.59 (1.37–4.89) | 0.003 | 1.51 (1.02–2.24) | 0.039 | 2.85 (1.58–2.15) | 0.001 | 1.66 (1.24–2.23) | 0.001 |
Female | 73/124 | 63/86 | 40/22 | 3.09 (1.70–5.60) | 0.000 | 2.48 (1.34–4.58) | 0.004 | 1.62 (1.09–2.41) | 0.017 | 2.80 (1.60–4.93) | 0.000 | 1.76 (1.31–2.36) | 0.000 |
Age (years) | |||||||||||||
<60 | 78/156 | 82/118 | 50/28 | 3.57 (2.09–6.11) | 0.000 | 2.57 (1.50–4.42) | 0.001 | 1.28 (0.82–2.01) | 0.277 | 3.05 (1.85–5.05) | 0.000 | 1.89 (1.46–2.45) | 0.000 |
≥60 | 68/100 | 40/64 | 24/14 | 2.52 (1.22–5.22) | 0.013 | 2.49 (1.16–5.35) | 0.019 | 1.81 (1.26–2.59) | 0.001 | 2.51 (1.25–5.06) | 0.010 | 1.43 (1.01–2.03) | 0.042 |
Smoking | |||||||||||||
Yes | 42/108 | 41/60 | 31/10 | 2.78 (1.57–4.93) | 0.000 | 2.81 (1.57–5.03) | 0.001 | 2.31 (1.43–3.73) | 0.001 | 2.79 (1.62–4.82) | 0.000 | 2.89 (2.01–4.15) | 0.000 |
No | 104/148 | 85/122 | 43/22 | 3.99 (2.05–7.76) | 0.000 | 2.27 (1.14–4.51) | 0.020 | 1.26 (0.90–1.79) | 0.183 | 3.14 (1.69–5.84) | 0.000 | 1.47 (1.13–1.91) | 0.004 |
Drinking | |||||||||||||
Yes | 40/80 | 40/52 | 20/10 | 4.08 (2.35–7.07) | 0.000 | 3.71 (2.11–6.53) | 0.000 | 1.53 (1.10–2.13) | 0.012 | 3.91 (2.31–6.63) | 0.000 | 1.77 (1.38–2.28) | 0.000 |
No | 106/176 | 86/130 | 54/22 | 2.00 (0.96–4.14) | 0.062 | 1.30 (0.62–2.73) | 0.490 | 1.67 (1.00–2.78) | 0.050 | 1.65 (0.84–3.25) | 0.148 | 1.47 (0.98–2.22) | 0.063 |
BMI | |||||||||||||
≥24 | 63/98 | 55/74 | 27/18 | 3.72 (2.13–6.52) | 0.000 | 2.97 (1.68–5.30) | 0.000 | 1.70 (1.18–2.45) | 0.004 | 2.19 (1.15–4.15) | 0.017 | 0.93 (0.66–1.30) | 0.677 |
<24 | 83/158 | 71/108 | 47/48 | 2.33 (1.19–4.58) | 0.014 | 2.02 (1.01–4.03) | 0.046 | 1.39 (0.90–2.14) | 0.140 | 3.38 (1.99–5.75) | 0.000 | 1.18 (0.90–1.55) | 0.219 |