Table 1. The list of patients with brain metastases evaluated in the present study.
| Case | Histological type of brain metastasis | Grade | Site of origin | Sex | Age | R tissue | SD R tissue | R blood | SD R blood |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Adenocarcinoma | G3 | Lung | F | 54 | 0.12 | 0.01 | 0.36 | 0.02 |
| 2. | Melanoma | – | Skin | F | 39 | 0.18 | 0.01 | – | – |
| 3. | Small cell carcinoma | G3 | Lung | F | 66 | 0.26 | 0.04 | – | – |
| 4. | Adenocarcinoma | G3 | Lung | F | 62 | 0.27 | 0.07 | 0.33 | 0.06 |
| 5. | Ductal carcinoma | – | Breast | F | 67 | 0.28 | 0.03 | – | – |
| 6. | Planoepithelial carcinoma | G3 | Lung | M | 69 | 0.28 | 0.03 | 0.48 | 0.02 |
| 7. | Transitional carcinoma | – | Bladder | M | 62 | 0.29 | 0.08 | – | – |
| 8. | Anaplastic small cell carcinoma | G3 | Lung | M | 67 | 0.29 | 0.08 | – | – |
| 9. | Tubular adenocarcinoma | G3 | Colon | M | 51 | 0.31 | 0.06 | 0.24 | 0.02 |
| 10. | Adenocarcinoma | – | Lung | F | 49 | 0.32 | 0.02 | 0.49 | 0.02 |
| 11. | Papillary carcinoma | – | Thyroid | F | 54 | 0.35 | 0.05 | 0.49 | 0.05 |
| 12. | Adenocarcinoma | G3 | Lung | F | 62 | 0.36 | 0.12 | – | – |
| 13. | Adenocarcinoma | – | Lung | F | 46 | 0.38 | 0.07 | – | – |
| 14. | Papillary adenocarcinoma | – | Endometrium | F | 60 | 0.38 | 0.04 | – | – |
| 15. | Adenocarcinoma | G3 | Lung | M | 55 | 0.38 | 0.04 | 0.36 | 0.04 |
| 16. | Adenocarcinoma | – | Lung | M | 50 | 0.41 | 0.05 | – | – |
| 17. | Papillary adenocarcinoma | G3 | Lung | M | 52 | 0.43 | 0.03 | – | – |
| 18. | Melanoma | – | Skin | F | 32 | 0.45 | 0.11 | – | – |
| 19. | Adenocarcinoma | – | Endometrium | F | 63 | 0.45 | 0.09 | – | – |
| 20. | Papillary adenocarcinoma | – | Lung | F | 68 | 0.45 | 0.03 | – | – |
| 21. | Adenocarcinoma | G3 | Oesophagus | M | 63 | 0.45 | 0.05 | – | – |
| 22. | Small cell carcinoma | G3 | Lung | M | 58 | 0.46 | 0.05 | 0.52 | 0.08 |
| 23. | Adenocarcinoma | G3 | Lung | M | 71 | 0.46 | 0.02 | 0.46 | 0.02 |
| 24. | Papillary adenocarcinoma | G2 | Lung | F | 64 | 0.47 | 0.02 | 0.43 | 0.02 |
| 25. | Papillary adenocarcinoma | – | Lung | M | 66 | 0.48 | 0.04 | – | – |
| 26. | Planoepithelial carcinoma | G3 | Lung | M | 72 | 0.48 | 0.09 | – | – |
| 27. | Solid carcinoma | – | Lung | M | 73 | 0.48 | 0.03 | – | – |
| 28. | Adenocarcinoma | G3 | Lung | F | 65 | 0.49 | 0.07 | – | – |
| 29. | Papillary adenocarcinoma | – | Lung | F | 68 | 0.49 | 0.05 | – | – |
| 30. | Adenocarcinoma | – | Lung | M | 56 | 0.49 | 0.07 | – | – |
| 31. | Clear cell renal cell carcinoma | – | Kidney | M | 56 | 0.49 | 0.07 | – | – |
| 32. | Planopithelial carcinoma | G3 | Lung | M | 64 | 0.49 | 0.07 | 1.12 | 0.05 |
| 33. | Small cell carcinoma | G3 | Lung | M | 65 | 0.49 | 0.07 | 0.56 | 0.04 |
| 34. | Adenocarcinoma | G3 | Lung | F | 59 | 0.50 | 0.10 | – | – |
| 35. | Solid carcinoma | – | Lung | F | 62 | 0.50 | 0.08 | – | – |
| 36. | Adenocarcinoma | – | Lung | M | 50 | 0.50 | 0.08 | – | – |
| 37. | Papillary adenocarcinoma | – | Colon | M | 60 | 0.50 | 0.10 | 0.69 | 0.04 |
| 38. | Anaplastic small cell carcinoma | G3 | Lung | F | 48 | 0.52 | 0.10 | – | – |
| 39. | Anaplastic small cell carcinoma | G3 | Lung | F | 66 | 0.52 | 0.05 | – | – |
| 40. | Adenocarcinoma | – | Lung | M | 48 | 0.52 | 0.08 | – | – |
| 41. | Adenocarcinoma | – | Lung | M | 49 | 0.52 | 0.08 | – | – |
| 42. | Melanoma | – | Skin | M | 51 | 0.52 | 0.07 | – | – |
| 43. | Papillary adenocarcinoma | – | Lung | M | 56 | 0.52 | 0.07 | – | – |
| 44. | Adenocarcinoma | G2 | Lung | M | 61 | 0.52 | 0.01 | 0.43 | 0.18 |
| 45. | Solid carcinoma | – | Lung | F | 52 | 0.53 | 0.05 | 0.52 | 0.03 |
| 46. | Planopithelial carcinoma | G3 | Lung | F | 54 | 0.53 | 0.07 | – | – |
| 47. | Solid carcinoma | – | Lung | F | 66 | 0.53 | 0.04 | – | – |
| 48. | Papillary adenocarcinoma | – | Lung | F | 44 | 0.54 | 0.04 | – | – |
| 49. | Ductal carcinoma | – | Breast | F | 50 | 0.54 | 0.09 | – | – |
| 50. | Solid carcinoma, poorly differentiated | G3 | Bladder | F | 52 | 0.54 | 0.06 | – | – |
| 51. | Papillary adenocarcinoma | – | Lung | F | 59 | 0.54 | 0.07 | – | – |
| 52. | Adenocarcinoma | – | Lung | F | 55 | 0.55 | 0.07 | – | – |
| 53. | Adenocarcinoma | G2 | Colon | F | 56 | 0.55 | 0.05 | – | – |
| 54. | Amelanotic melanoma | – | Skin | M | 44 | 0.55 | 0.07 | – | – |
| 55. | Solid carcinoma | – | Lung | M | 65 | 0.55 | 0.05 | – | – |
| 56. | Adenocarcinoma | – | Lung | F | 48 | 0.56 | 0.09 | – | – |
| 57. | Solid carcinoma | – | Lung | M | 50 | 0.56 | 0.08 | – | – |
| 58. | Anaplastic small cell carcinoma | G3 | Lung | M | 64 | 0.56 | 0.04 | 0.68 | 0.04 |
| 59. | Melanoma | – | Skin | F | 55 | 0.57 | 0.05 | 0.72 | 0.06 |
| 60. | Melanoma | – | Skin | M | 54 | 0.57 | 0.05 | – | – |
| 61. | Adenocarcinoma | – | Lung | M | 57 | 0.57 | 0.07 | – | – |
| 62. | Papillary carcinoma | – | Lung | M | 62 | 0.57 | 0.05 | – | – |
| 63. | Adenocarcinoma | – | Lung | M | 70 | 0.57 | 0.05 | – | – |
| 64. | Adenocarcinoma | – | Lung | F | 47 | 0.58 | 0.04 | – | – |
| 65. | Solid carcinoma | – | Lung | F | 48 | 0.58 | 0.08 | – | – |
| 66. | Papillary adenocarcinoma | G2 | Lung | F | 68 | 0.58 | 0.08 | – | – |
| 67. | Adenocarcinoma | – | Lung | M | 49 | 0.58 | 0.03 | 0.97 | 0.05 |
| 68. | Adenocarcinoma | G3 | Lung | M | 58 | 0.58 | 0.05 | – | – |
| 69. | Adenocarcinoma | – | Lung | M | 58 | 0.58 | 0.03 | – | |
| 70. | Anaplastic small cell carcinoma | G3 | Lung | F | 40 | 0.59 | 0.06 | – | – |
| 71. | Adenocarcinoma | G2 | Lung | F | 48 | 0.59 | 0.05 | 0.58 | 0.08 |
| 72. | Papillary adenocarcinoma | G2 | Lung | M | 60 | 0.59 | 0.06 | 0.43 | 0.07 |
| 73. | Papillary adenocarcinoma | – | Lung | M | 50 | 0.60 | 0.08 | – | – |
| 74. | Solid carcinoma, poorly differentiated | G3 | Lung | M | 62 | 0.60 | 0.06 | 0.36 | 0.02 |
| 75. | Solid carcinoma | – | Lung | M | 72 | 0.60 | 0.03 | 0.33 | 0.02 |
| 76. | Papillary adenocarcinoma | – | Breast | F | 55 | 0.61 | 0.12 | – | – |
| 77. | Clear cell adenocarcinoma | – | Lung | M | 58 | 0.61 | 0.07 | – | – |
| 78. | Planoepithelial carcinoma, akeratotic | G3 | Lung | M | 59 | 0.61 | 0.06 | 0.78 | 0.03 |
| 79. | Solid carcinoma | – | Lung | F | 48 | 0.62 | 0.07 | – | – |
| 80. | Solid carcinoma | – | Lung | M | 64 | 0.63 | 0.07 | – | – |
| 81. | Adenocarcinoma | – | Prostate | M | 46 | 0.64 | 0.03 | – | – |
| 82. | Solid carcinoma, poorly differentiated | G3 | Lung | M | 56 | 0.64 | 0.09 | – | – |
| 83. | Papillary adenocarcinoma | G2 | Lung | M | 57 | 0.64 | 0.04 | 0.65 | 0.06 |
| 84. | Solid carcinoma | – | Lung | M | 46 | 0.66 | 0.13 | – | – |
| 85. | Planoepithelial carcinoma, akeratotic | G2 | Lung | M | 66 | 0.66 | 0.15 | – | – |
| 86. | Adenocarcinoma | G3 | Lung | M | 66 | 0.66 | 0.09 | 0.53 | 0.02 |
| 87. | Sarcoma | – | Endometrium | F | 62 | 0.67 | 0.08 | – | – |
| 88. | Papillary adenocarcinoma | – | Lung | M | 65 | 0.67 | 0.16 | – | – |
| 89. | Solid carcinoma, poorly differentiated | G3 | Lung | M | 65 | 0.69 | 0.07 | – | – |
| 90. | Adenocarcinoma | – | Lung | M | 73 | 0.69 | 0.05 | 0.67 | 0.06 |
| 91. | Papillary adenocarcinoma | G2 | Breast | F | 51 | 0.70 | 0.10 | 0.98 | 0.05 |
| 92. | Adenocarcinoma | – | Lung | F | 49 | 0.71 | 0.02 | – | – |
| 93. | Embryonal carcinoma | – | Testis | M | 52 | 0.71 | 0.06 | – | – |
| 94. | Clear cell adenocarcinoma | – | Lung | M | 56 | 0.71 | 0.02 | – | – |
| 95. | Large cell carcinoma | G3 | Lung | F | 56 | 0.72 | 0.06 | – | – |
| 96. | Adenocarcinoma | – | Lung | M | 51 | 0.72 | 0.04 | – | – |
| 97. | Adenocarcinoma | – | Colon | M | 54 | 0.72 | 0.01 | – | – |
| 98. | Large cell carcinoma | G3 | Lung | M | 54 | 0.72 | 0.01 | 0.94 | 0.02 |
| 99. | Large cell carcinoma | G3 | Lung | M | 65 | 0.73 | 0.06 | – | – |
| 100. | Melanoma | – | Skin | M | 77 | 0.73 | 0.06 | 0.98 | 0.06 |
| 101. | Embryonal carcinoma | – | Testis | M | 46 | 0.74 | 0.09 | – | – |
| 102. | Solid carcinoma, poorly differentiated | G3 | Lung | M | 51 | 0.75 | 0.05 | 0.54 | 0.01 |
| 103. | Melanoma | – | Skin | M | 63 | 0.75 | 0.09 | – | – |
| 104. | Adenocarcinoma | G3 | Lung | M | 63 | 0.76 | 0.12 | – | – |
| 105. | Papillary adenocarcinoma | G2 | Breast | F | 68 | 0.77 | 0.08 | 0.68 | 0.04 |
| 106. | Papillary adenocarcinoma | G2 | Lung | F | 60 | 0.78 | 0.09 | – | – |
| 107. | Adenocarcinoma | – | Breast | M | 57 | 0.78 | 0.05 | – | – |
| 108. | Adenocarcinoma | – | Lung | M | 62 | 0.79 | 0.07 | – | – |
| 109. | Adenocarcinoma | – | Lung | F | 57 | 0.82 | 0.11 | – | – |
| 110. | Planoepitheliale carcinoma | G3 | Lung | M | 49 | 0.82 | 0.09 | – | – |
| 111. | Anaplastic small cell carcinoma | G3 | Lung | M | 50 | 0.82 | 0.03 | 0.88 | 0.02 |
| 112. | Tubular papillary adenocarcinoma | G2 | Colon | M | 53 | 0.82 | 0.09 | – | – |
| 113. | Planoepithelial carcinoma | – | Tongue | M | 55 | 0.82 | 0.09 | – | – |
| 114. | Large cell carcinoma | – | Lung | M | 61 | 0.82 | 0.06 | 0.61 | 0.07 |
| 115. | Adenocarcinoma | – | Breast | F | 53 | 0.84 | 0.04 | – | – |
| 116. | Papillary adenocarcinoma | G2 | Lung | M | 64 | 0.84 | 0.09 | 0.95 | 0.04 |
| 117. | Papillary adenocarcinoma | G2 | Lung | F | 56 | 0.85 | 0.02 | 0.67 | 0.06 |
| 118. | Adenocarcinoma | G3 | Lung | M | 52 | 0.85 | 0.04 | 0.76 | 0.01 |
| 119. | Tubular adenocarcinoma | G2 | Colon | M | 49 | 0.86 | 0.07 | 0.70 | 0.05 |
| 120. | Papillary adenocarcinoma | G2 | Lung | M | 55 | 0.86 | 0.07 | – | – |
| 121. | Papillary adenocarcinoma | G2 | Lung | M | 58 | 0.87 | 0.06 | 0.86 | 0.19 |
| 122. | Adenocarcinoma | G1 | Lung | F | 54 | 0.92 | 0.04 | – | – |
| 123. | Papillary adenocarcinoma | – | Lung | M | 67 | 0.93 | 0.10 | – | – |
| 124. | Papillary adenocarcinoma | G1 | Lung | M | 69 | 0.93 | 0.04 | 0.96 | 0.04 |
| 125. | Small cell carcinoma | – | Lung | M | 57 | 0.96 | 0.04 | – | – |
| 126. | Papillary adenocarcinoma | – | Lung | F | 58 | 0.97 | 0.03 | 1.19 | 0.07– |
| 127. | Papillary adenocarcinoma | G3 | Lung | M | 60 | 0.98 | 0.03 | 0.96 | 0.01 |
| 128. | Papillary adenocarcinoma | – | Ovary | F | 61 | 0.99 | 0.15 | 0.71 | 0.06 |
| 129. | Mucocellular papillary adenocarcinoma | – | Colon | M | 51 | 1.01 | 0.09 | 1.18 | 0.08 |
| 130. | Large cell carcinoma | – | Lung | M | 55 | 1.02 | 0.12 | – | – |
| 131. | Papillary adenocarcinoma | G2 | Lung | F | 61 | 1.03 | 0.01 | 0.82 | 0.07 |
| 132. | Papillary adenocarcinoma | – | Colon | F | 67 | 1.08 | 0.14 | – | – |
| 133. | Small cell carcinoma | – | Lung | F | 54 | 1.09 | 0.03 | 0.92 | 0.09 |
| 134. | Papillary adenocarcinoma | – | Kidney | M | 64 | 1.09 | 0.02 | – | – |
| 135. | Papillary adenocarcinoma | – | Ovary | F | 50 | 1.13 | 0.06 | – | – |
| 136. | Papillary adenocarcinoma | – | Ovary | F | 55 | 1.18 | 0.17 | – | – |
| 137. | Papillary serous cystadenocarcinoma | G2 | Ovary | F | 52 | 1.23 | 0.03 | – | – |
| 138. | Adenocarcinoma | G3 | Lung | F | 54 | 1.24 | 0.07 | – | – |
| 139. | Planoepithelial carcinoma | G3 | Larynx | M | 64 | 1.31 | 0.13 | – | – |
The histological types and grades were estimated in routine pathological report.–: not estimated; G1: well differentiated; G2: moderately differentiated; G3: poorly differentiated.