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. 2018 Oct 24;4:38. doi: 10.1038/s41540-018-0074-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Identification of 83 upregulation events that occur in early stages. a Hierarchical clustering of 219 EEA genes in TNBC patients. Different colors show TNBC patients clustered into four clusters represented as Red for Cluster 1 (C1), Purple for Cluster 2 (C2), Blue for Cluster 3 (C3), and Green for Cluster 4 (C4). b The progression of gene upregulations in different TNBC clusters as shown by the phylogenetic tree. The figure shows the lineage of progression of gene upregulations from the normal to distinct subpopulations. Heat maps with genes in columns and TNBC samples in rows display the upregulation status (yellow: no upregulation; blue: upregulation) for different TNBC clusters. c Correlation clustergram of cluster 1 genes compared to known tumor suppressors. Red indicates negative correlation and green indicates positive correlation. The panel on the right represents, the significance of the correlation as a heat map. Blue indicates significance (<0.05) and white indicates lack of significance (>0.05)