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. 2018 Oct 24;4:38. doi: 10.1038/s41540-018-0074-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Survival plot and a model describing the role of cluster 1 genes in tumor evolution. a Representative relapse-free survival plots of breast cancer patients with low and high expression of cluster 1 genes. b Survival plots of TNBC patients with high and low multivariate gene expression score. c Schematic model showing the effect of simultaneous burst of CIN and TME-associated genes in response to hypoxia during early stages of cancer initiation