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. 2018 Oct 24;8:15737. doi: 10.1038/s41598-018-34018-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of TNFα-induced NFκB activation in human NSCLC cells. (A) Confocal images (40x magnification) showing the levels of p-NF-κB. (B) Western blot analysis depicting levels of p-NFκB, total NF-kB, p-IκB, and total IκB in whole cell lysates following stimulation with TNFα (25 ng/mL (C) Western blot analysis of nuclear and cytosolic cell extracts depicting levels of NFκB, p-NFκB, IκBα, and p-IκBα following stimulation with TNFα. (D) Electrophoretic mobility shift assay, indicating the inhibition of NF-κB binding to DNA. Cells were incubated with WFA for 4 h and then stimulated with TNFα (25 ng/mL). Band intensity represents the extent of DNA binding.