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. 2018 Oct 24;8:15711. doi: 10.1038/s41598-018-34148-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene targeting and generation of TALEN-mediated Pgrmc1 mutant mice. (A) Target region of Pgrmc1-TALEN in mouse Pgrmc1 locus. (B) T7E1-based mutation detection assays and sequencing analysis. The numbers indicated wild type (WT, in black) and mutant (in red) mice. Colored sequences of Pgrmc1 indicate TALEN binding sites. “-” denoted deleted nucleotides. M, a molecular size marker. (C) Pgrmc1 mutant founder #1 was crossed to WT mouse and the genotypes of the pups were determined by PCR analysis.