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. 2018 Oct 18;12:371. doi: 10.3389/fncel.2018.00371

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Copyright © 2018 Yu, Duan, Zhao, He, Xia, Zhang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Middle cerebral artery occlusion (MCAO) model was evaluated to be suitable for studying the pharmacology efficacy of Hydroxysafflor yellow A (HSYA). (A) Neurological scores, (B) brain edema, (C) infarct volume, (D) pictures of infarct volume. The values are shown as means ± SEM. Significant difference between sham group vs. MCAO group in neurological scores (sham, n = 8; MCAO, n = 8, ****P < 0.0001), brain edema (sham, n = 2; MCAO, n = 6, **P < 0.01) and infarct volume (sham, n = 2; MCAO, n = 8, ****P < 0.0001).