Figure 3.

Analysis of the TBC1D7 structure. A, conservation of TBC1D7 structure calculated using the ConSurf web server. Side chains of the most conserved residues are shown as sticks, whereas the rest are shown in thin lines. The enlarged insert shows the conserved salt bridge formed between residues Arg-56 and Asp-225 from helices α3 and α12 from the N- and C-subdomains, respectively. B, surface electrostatic potential of TBC1D7. Blue, positively charged residues; red, negatively charged residues.