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. 2018 Sep 14;293(42):16261–16276. doi: 10.1074/jbc.RA118.005531

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© 2018 Wu et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — HTLV-1 gRNA-derived 5′ leader constructs (HTLV-1_CH isolate) used in this study. A, Mfold-predicted secondary structures (101) of short gRNA constructs SL(450–470), SL(474–508), and SL(447–512) derived from the putative HTLV-1 packaging signal within the gag coding region. B, schematic representation of HTLV-1 5′ leader and three constructs encompassing the 5′-UTR (R and U5) and the 5′ end of the gag coding region (5′ gag). The locations of SL(450–470) and SL(474–508) as well as the SD and PBS are indicated.