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. 2018 Aug 30;293(42):16193–16205. doi: 10.1074/jbc.RA118.003699

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© 2018 Elkhadragy et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 7. — The S189 mutation decreases the ability of ERK3 to up-regulate the expression of MMP10 and MMP9 genes. A and B, quantitative RT-PCR analysis of MMP10 (A) and MMP9 (B) gene expression in A549 cells with stable expression of an empty vector, ERK3, ERK3-S189A, or ERK3-KD as described in Fig. 1C. Values in the bar graphs represent mean ± S.D. (n = 3). **, p < 0.0001 (significantly different compared with empty vector); *, p < 0.05 (significantly different compared with empty vector); #, p < 0.005 (significantly different compared with ERK3); one-way ANOVA.